Statistical issues in survival analysis (bias in HR for group sequential)
May 21, 2025 The authors focused on adjustment for conditional bias in hazard ratios from overall survival (OS) in both interim and final analysis in trial where the overall hierarchical strategy was applied. They first showed a conditional bias (CB) adjusted...
Statistical issues in survival analysis (joint latent classes tutorial)
May 7, 2025 The authors have presented a tutorial on joint latent class models (JLCMs), which are a statistical approach to allowing to simultaneously account for two outcomes related to disease progression, a longitudinal measure and a time-to-event measure. A linear...
Statistical issues in survival analysis (sample size for tests based on RMST)
April 23, 2025 The authors have discussed a sample size calculation for restricted mean survival time (RMST) in augmented tests. The RMST was developed as an alternative measure of survival that is non-parametric and does not reply on parametric constraints. It had...
Statistical issues in survival analysis (Pseudo-observations bivariate survival)
April 9, 2025 The authors have generalized the pseudo-observations approach to bivariate survival data subject to right censoring. Pseudo-observations approach was originally developed by Anderson (2003) for estimating covariates effect on time-to-event data. This...
Statistical issues in survival analysis (Lindley frailty model)
March 26, 2025 Their primary goal of their paper was to introduce a novel frailty model based on the weighted Lindley (WL) distribution for modeling clustered survival data. They used the weighted Lindley as the frailty distribution. This was a two parameter...
Statistical issues in survival analysis (Wavelet survival models)
March 12, 2025 The authors used a novel method based on wavelet filtering and landmarking to obtain the prognostic role of a biomarker in patient death. Wavelet filters have been common in time series data to extract features and reduce noise. They also utilized...
Statistical issues in survival analysis (Meta-analysis & RMSE)
February 26, 2025 The authors have used network meta-analysis (NMA) to compare multiple treatments simultaneously using restricted mean survival time (RMST) with individual level data (IPD). Since the NMA was mainly used with aggregate data, they had to extend this...
Statistical issues in survival analysis (Causal mediation additive hazards)
February 12, 2025 The authors focused on causal mediation analysis in survival analysis, more specifically with additive hazards modeling with an exposure by mediator interaction term. The causal mediation framework had come about over time from the mediation area and...
Statistical issues in general (informative clusters)
January 29, 2025 Many analyses have used clustered data but not everyone considers that clusters may be informative. For example, generalized estimating equations (GEE) and marginal proportional hazards model have been widely used to estimate population-average...
Statistical issues in survival analysis (Part XVVVVVVII)
January 15, 2025 In this paper the authors proposed prognostic accuracy measures for recurrent event data. They did so by developing semiparametric estimators for making inferences about the prognostic accuracy measures that accommodate recurrent events. Usually a...