by Usha Govindarajulu | Jun 3, 2026 | Biostatistics, Blog, Usha Govindarajulu
June 3, 2026 The authors evaluated the performance of targeted maximum likelihood estimation (TMLE) for estimating the average treatment effect in missing data scenarios under varying levels of positivity violations. Directed acyclic graphs (DAGs) have been used in...
by Usha Govindarajulu | May 20, 2026 | Biostatistics, Blog, Usha Govindarajulu
May 20, 2026 Unmeasured confounding has been a long-standing methodological challenge for causal inference and these confounding mechanisms can violate the ignorability assumption that is a bedrock of causal inference. As they say, the profound implications of this...
by Usha Govindarajulu | May 6, 2026 | Biostatistics, Blog, Usha Govindarajulu
May 6, 2026 The win ratio introduced by Pocock et al (2012) has become a popular measure to summarize composite endpoints in clinical trials. It essentially prioritizes important events over lesser ones using an effect size as the relative frequency of wins (more...
by Usha Govindarajulu | Apr 22, 2026 | Biostatistics, Blog, Machine Learning, Usha Govindarajulu
April 22, 2026 Written by, In this article, they studied regression analysis of arbitrarily censored and left-truncated data under a popular semiparametric proportional odds model. They developed a new estimation approach via an expectation and maximization algorithm...
by Usha Govindarajulu | Apr 8, 2026 | Biostatistics, Blog, Usha Govindarajulu
April 8, 2026 The Restricted Mean Survival Time (RMST) is a metric to compare survival between two treatment groups without relying on proportional hazards, especially that hazard ratios are constant over time. For covariate adjustment, Andersen et al’s (2004) method...
by Usha Govindarajulu | Mar 25, 2026 | Biostatistics, Blog, Usha Govindarajulu
March 25, 2026 The goal of this article was to present a methodology to design and analyze an adaptive clinical trial with sample size recalculation at interim analysis, when the restricted mean survival time (RMST) is the primary endpoint. Especially, we focus on the...
