by Usha Govindarajulu | Sep 1, 2021 | Biostatistics, Blog, Epidemiology, Healtcare, Usha Govindarajulu
Waning of efficacy and interpretation A lot of controversy has come up with the boosters for the COVID-19 vaccines and efficacy. The Israeli study on efficacy comparing people vaccinated last year to people vaccinated this year seemed to indicate the efficacy...
by Usha Govindarajulu | Aug 4, 2021 | Biostatistics, Blog, Usha Govindarajulu
As we have heard or know, COVID-19 research, especially in early 2020, was filled with observational studies, many of which were potentially underpowered, but it turns out, even randomized controlled trials. Sample size estimation went out the window. Even Lee...
by Usha Govindarajulu | Jul 21, 2021 | Biostatistics, Blog, Healtcare, Professor, Usha Govindarajulu
With all the news about vaccine efficacy and how long the effects of the vaccine will last, it is interesting to wonder how the statistical models to detect such effects are designed for such research . In the Khoury et al paper (2020), they do consider the decay of...
by Usha Govindarajulu | Jul 9, 2021 | Biostatistics, Blog, Epidemiology, Healtcare, Professor, Usha Govindarajulu
Re-analyses on vaccine efficacy in COVID-19 research Much of the news these days focuses on vaccine efficacy rates being re-updated due to various new COVID-19 variants coming out often, originating in different countries, like delta (B.1.167.2) from India and lambda...
by Usha Govindarajulu | Jun 23, 2021 | Biostatistics, Blog, Professor, Usha Govindarajulu
Bayesian methods used in COVID-19 research During the times of uncertainty in statistical methods used in COVID-19 research. Were Bayesian methods employed much in these contexts? Yes they were here and there but probably once again, just like in regular research,...
by Usha Govindarajulu | Jun 9, 2021 | Biostatistics, Blog, Healtcare, Professor, Usha Govindarajulu
P-values and vaccine efficacy As the companies continue to re-evaluate vaccine efficacy against new variants, have they discussed p-values? Are they analyzing re-updated data again and again and correcting for inflation of the Type I error rate?? Given the...
